HERC2 and OCA2 genes polimorphisms in relation to the iris color variation of the Belarusian population

The human genetic phenotyping is one of the most intensely developing area forensic genetics. Externally visible traits, including eye color, can be predicted by analyzing single nucleotide polymorphisms with a high predictive rate. We studied rs12913832 and rs1800407 in HERC2 OCA2 genes, respectively, to evaluate its prognostic availability relation iris pigmentation Belarusian population. For this, both images DNA samples were collected from 314 individuals analyze key TaqMan assay. Our data confirmed relevance rs12913832:A>G rs1800407:G>A prediction context. highest values sensitivity (SE = 0.94) specificity (SP 0.90) obtained for rs12913832, demonstrating efficiency this marker as classifier phenotypic groups. presence ancestral dominant allele rs12913832-A causes dark (brown) pigmentation, how- ever, heterozygous state rs12913832:GA includes range mixed variants. value highly significant 0.98), but has low 0.14), thus rs1800407, not being an effective classifier, used auxiliary color model. analysis cumulative impact poly- morphisms on variation shows their prospects